The discovery of scientists from the University of Warsaw supporting the treatment of breast cancer.

05 07 2023

This is the next stage of genetic progress, which in the future may significantly affect our health and improve the processes of treatment and prevention of the disease.

Researchers from The University of Warsaw, Dr. Stefano Volinia (CNBCh) and Dr. Jeff Palatini (CeNT) and collaborators from the University of Ferrara recently had their work featured on the cover of the Journal Non-Coding RNA (CiteScore 9.6). You can find a short description of the work along with a link to the article below. Please direct any questions to Dr. Jeff Palatini, on the following email: j.palatini@cent.uw.edu.pl

“The cellular roles of circular RNAs (circRNAs) are widely studied; albeit little is known about the effects of drugs on their expression and relationship with the cognate linear transcript (linRNA). Focusing on breast cancer, we tested various anticancer agents in two cell lines that comprise a panel of drug-modulated circRNAs/linRNAs.

According to their oncogenic or anticancer role, we observed the upregulation of circRNA and downregulation of linRNA within the same gene in association with specific mutated pathways, such as PI3K/AKT in MCF-7 or the NHEJ DNA repair pathway in the TP53-mutated MDA-MB-231 cell. Interestingly, only XL765 did not alter tumorigenic circ/linRNAs in MCF-7, and AMG511 and GSK1070916 decreased circGFRA1, as drug effectiveness in MDA-MB-231 cells.

View this paper: https://www.mdpi.com/2311-553X/9/3/32