W ostatnim numerze Journal of the American Chemical Society (JACS) pojawił się artykuł autorstwa pracowników grupy badawczej Laboratorium Syntezy Metaloorganicznej, której kierownikiem jest
prof. dr hab. inż. Karol Grela.
JACS to jeden z najbardziej prestiżowych czasopism związanych z wiedzą chemiczną.

At Long Last: Olefin Metathesis Macrocyclization at High Concentration
Adrian Sytniczuk, Michał Dąbrowski, Łukasz Banach, Mateusz Urban, Sylwia Czarnocka-Śniadała, Mariusz Milewski, Anna Kajetanowicz, Karol Grela

link do artykułu:
https://pubs.acs.org/doi/10.1021/jacs.8b04820?hootPostID=963765df50f096a121d65e9e2a821b4d&

ABSTRACT: Macrocyclic lactones, ketones and ethers can be obtained in the High-Concentration Ring-Closing Metathesis (HC-RCM) reaction in high yield and selectivity at concentrations 40 to 380 times higher than those typically used by organic chemists for similar macrocyclizations. New method consist of using tailored ruthenium catalysts together with applying vacuum to distill off the macrocyclic product as it is formed by the metathetical backbiting of oligomers. Unlike classical RCM, no large quantities of organic solvents are used, but rather inexpensive non-volatile diluents, such as natural or synthetic paraffin oils. Moreover, use of protecting atmosphere or a glovebox is not needed as the new catalysts are perfectly moisture and air stable. In addition some other cyclic compounds previously reported as unobtainable by RCM in neat, or in high dilutions even, can be formed with help of HC-RCM method.

 

środa, Lipiec 4, 2018 - 14:10