DESCRIPTION OF THE GROUP
This group focuses on research on proteins, especially in cellular membranes. These studies regard, among others, mechanism of GPCR receptors activation (G-protein-coupled receptors) and functioning of molecular switches in the above mentioned receptors. Biomodeling enables group members to predict ligand activity, in order to design appropriate selective drugs.
The second scientific interest of this group is research on structure and dynamics of proteins forming γ-secretase complex. Models of interaction between these proteins may help to understand the role of mutations causing Alzheimer’s disease and to clarify, which structural modifications in the substrate-binding site influence the change of the cutting place and formation of toxic β-amyloid (Aβ42).