DESCRIPTION OF THE GROUP

Scientific interest of the Laboratory of Biologically Active Compounds is focused on solving problems of structure-activity relationship (SAR) in biologically active compounds. Apart from designing, synthesis and determination of structure and properties of new particles, which are typical chemical problems, the Laboratory’s work includes also pharmacological research, both in vitro and in vivo. Such studies demand close cooperation between chemists and pharmacologists.

Professor Aleksandra Misicka-Kęsik team’s scientific research:
Scientific research of professor Aleksandra Misicka-Kęsik’s team concentrates on designing and synthesizing peptide analogues and peptidomimetics, characterized by antiangiogenic activity through blocking the VEGF165/VEGFR2/NRP-1 complex.

Professor Rafał Siciński team’s scientific research:
Longterm studies on vitamin D group of compounds enabled scientists to determine, that calcitriol (vitamin-hormone), apart from regulating calcium and phosphate concentrations in the blood, also controls the division and differentiation of cells and participates in the immunological processes. Such a diverse range of actions stimulated scientists to start research with the aim of finding structurally modified analogues of calcitriol, characterized by selective activity.

The Laboratory of Biologically Active Compounds is equipped with: LCMS 8058 double quadrupole mass spectrometer coupled with UPLC, GC-MS-QP2010 Ultra EI single quadrupole mass spectrometer coupled with gas chromatograph, LCMS-IT-TOF mass spectrometer, MALDI-TOF Axima Performance mass spectrometer, Activo-P11 automated peptide synthesizer by Activotec.